According to Rolling Stone writer Rob Kemp, S.C.I.E.N.C.E. incorporates elements of multiple genres, including heavy metal, electro, funk, jazz, hip hop and techno.

The soundtrack was released on Jby Epic/Immortal, and featured a collaboration with DJ Greyboy called 'Familiar'. was in the process of being recorded and mastered, the band went on some local mini-tours, in addition to appearing on the soundtrack for the movie Spawn. With that kind of support, we just let everything kind of run wild.' They kinda just said, 'do whatever you want'. He doesn't try to change what we do, he tries to enhance it.' He also said, 'when we signed our record deal and started working on this album, we were worried that someone would come along and tell us to hold back, and try and make our songs a little more palatable. Guitarist Mike Einziger believed that Wirt helped encourage their creativity during the recording of S.C.I.E.N.C.E., saying in 1997, 'he helps us come up with strange stuff and he likes it when we do. Very different experience, but very important on this band's existence.' During the recording, the band utilized older analogue gear that they described as having 'phat sounds and spider webs.' Incubus chose Jim Wirt to produce the album, since he had worked with them on earlier recordings. was done in six weeks at 4th Street Recording, a very small, charming studio in Santa Monica.

Singer Brandon Boyd said ' S.C.I.E.N.C.E. Their first full-length major label effort S.C.I.E.N.C.E. With Enjoy Incubus, the label's strategy was to build the band's fanbase through touring rather than radio airplay. An EP titled Enjoy Incubus was released by Epic/Immortal at the beginning of 1997, and Incubus would go on a European tour with labelmates Korn for the next few months. After recording their independent debut album Fungus Amongus, Incubus signed a seven-record deal with Epic Records/Sony-affiliated Immortal Records.

Incubus band mascot guy